News for Healthier Living
Double Trouble: Gene-Regulating Duo Shapes Cell Fate and Disease
 Shedding light on what determines how cells become what they are meant to be--nerves, bone, muscles, etc.--can also help researchers understand how diseases develop when these biological programs break down.
Now, researchers at Case Western Reserve University have discovered a key synergistic role for two epigenetic markers--molecules that help tell genes to turn on and off--involved in programming cell fate. Importantly, turning off these two markers causes genes to over-activate, disrupting normal cell development.
August 14, 2025
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